纳/微米材料及器件的生物医学应用虚拟专辑代表性论文6：牛血清白蛋白耦联磁性Fe3O4 纳米颗粒提高生物相容性与磁热疗性能
【引言】
摘要
磁热疗法是一种快速发展的非侵入性肿瘤治疗手段。National University of Singapore的Jun Ding等人利用热分解法制备了10nm超顺磁性和30nm铁磁性两种Fe3O4纳米颗粒，并利用即表面电荷吸附和酰胺键共价修饰两种方法在Fe3O4 纳米颗粒接入牛血清白蛋白（BSA）分子。初步的溶血和细胞毒性实验表明，表面共轭BSA分子降低了Fe3O4颗粒对红细胞的溶血作用，且对健康的仓鼠肾细胞无细胞毒性。BSA-铁磁性Fe3O4具有高生物相容性：溶血指数<2%，细胞存活率达120%。
这篇综述文章发表于Nano-Micro Letters上2016年第8卷第1期.
全文链接：
文章引用信息：
Viveka Kalidasan . Xiao Li Liu . Tun Seng Herng . Yong Yang . Jun Ding,Bovine Serum Albumin-Conjugated Ferrimagnetic Iron Oxide Nanoparticles to Enhance the Biocompatibility and Magnetic Hyperthermia Performance,Nano-Micro Lett. Nano-Micro Lett. (2016) 8(1):80–93, http://dx.doi:10.1007/s40820-015-0079-8
【图文导读】
Fig. 1 Schematic representation of (a) physical adsorption of BSA to CTAB; (b) strong covalent amide bond formation between BSA and APTMS
Fig. 2 Characterization of as-synthesized iron oxide nanoparticles( a )TEM images of (i) 10 nm SPIONs and (ii) 30 nm FIONs. (b) XRD plots of SPIONs and FIONs
Fig. 3 Characterization of magnetic properties of the as-synthesized iron oxide nanoparticles( a) Saturation magnetization values of SPIONs and FIONs using VSM. The inset figure shows the coercivity of FIONs. SQUID measurements showing the(b) Verwey transition temperature (Tv) of 115 K deduced from the ZFC plot for FIONs.( c) Magnetization hysteresis loops of FIONs at different temperatures
Fig. 4 Average hydrodynamic radius of surface modified iron oxide nanoparticles( a) CTAB- SPIONs; (b) CTAB-FIONs; (c) APTMS-SPIONs; (d) APTMS-FIONs. Inset images in (b) show the stable solution of CTAB-FIONs and TEM images of the same
Fig. 5 Average hydrodynamic radius of surface modified iron oxide nanoparticles as a function of time
Fig. 6 FTIR plots for iron oxide nanoparticles surface modified with (a) CTAB (b) APTMS
Fig. 7 (a )UV–Vis spectrum for (i) CTAB-iron oxide nanoparticles, (ii) APTMS-iron oxide nanoparticles, (iii) BSA (iv) BSA-CTAB-iron oxide nanoparticles, (v) BSA-APTMS-iron oxide nanoparticles. (b) Zetapotential values surface modified and BSA-conjugated iron oxide nanoparticles
Fig. 8 Average hydrodynamic size of BSA-conjugated, surface modified iron oxide nanoparticles (a) BSA-CTAB-SPIONs, (b) BSA-CTABFIONs, (c) BSA-APTMS-SPIONs and (d )BSA- APTMS-FIONs. The inset images in (b) show the stable colloidal solution and TEM image of BSACTAB-FIONs
Fig. 9 Average hydrodynamic radius of BSA-conjugated, surface modified iron oxide nanoparticles as a function of time
Fig. 10 Haemolytic effect of test samples (a) as-synthesized iron oxide nanoparticles; (b) CTAB-iron oxide nanoparticles; (c) BSA-CTAB-iron oxide nanoparticles; (d) APTMS-iron oxide nanoparticles; (e) BSAAPTMS-iron oxide nanoparticles
Fig. 11 Mechanism of haemolysis
Fig. 12 Haemolytic index of the (a) BSA-conjugated CTAB-iron oxide nanoparticles; (b) BSA-conjugated APTMS-iron oxide nanoparticles
Fig. 13 The BSA-conjugated APTMS-FIONs exhibit higher percentage of cell viability than the non-conjugated FIONs
Fig. 14 Heating characteristics (a) temperature raise comparison between BSA-CTAB-iron oxide nanoparticles and CTAB-iron oxide nanoparticles;( b) SAR value comparison between BSA-CTAB-iron oxide nanoparticles and CTAB-iron oxide nanoparticles; (c) Temperature raise comparison between BSA-APTMS-iron oxide nanoparticles and APTMS-iron oxide nanoparticles; (d )SAR value comparison between BSAAPTMS-iron oxide nanoparticles and APTMS-iron oxide nanoparticle
虚拟专辑（二）纳/微米材料及器件的生物医学应用
本期虚拟专辑主要介绍纳米材料及器件在生物医学领域的研究，选自近两年发表在Nano-Micro Letters上的9篇代表性论文，敬请阅读并复制链接打开下载（免费），并欢迎投稿。
⊙ 1. 综述：微流体在乳腺癌诊断方面的应用
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⊙ 2. 综述：电化学纳米医学传感器在生物医学领域的应用展望
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⊙ 3. 综述：ZnO纳米颗粒的抗菌活性和毒性机制
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⊙ 4. 金纳米颗粒单层和多层细胞模型在纳米-微界面上相互作用的尺寸依赖性
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⊙ 5. 具有高抗菌抗癌特性的碳纳米管内嵌植物化学官能化Cu/Ag纳米颗粒复合物
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⊙ 6. 牛血清白蛋白耦联磁性Fe3O4 纳米颗粒提高生物相容性与磁热疗性能
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⊙ 7. 细胞在阳极氧化的多尺寸二氧化钛纳米管阵列表面的行为研究
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⊙ 8.利用多层细胞培养模型揭示纳米颗粒在实体肿瘤中的吸收和分布
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⊙ 9. 阳离子多赖氨酸修饰磁性氧化铁纳米粒颗粒用于肺癌细胞高效标记
链接10.1007/s40820-015-0053-5
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